| Autor: |
Tobias Schmelzle, Marta Cortes-Cros, Francesco Hofmann, Volker M. Stucke |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Target Identification and Validation in Drug Discovery ISBN: 9781627033107 |
| Popis: |
The advent of a variety of genomic, proteomic and other system-based scientific approaches has raised the expectations of identifying novel targets for oncology drug discovery. However, the complexity of human genome cancer alterations requires a careful analysis of the function of candidate targets identified by these efforts. The postulation and testing of a hypothesis that modulation of a protein or pathway will result in a therapeutic effect in a preclinical setting is crucial for target validation activities. In this chapter, we provide an overview on target identification and validation approaches to interrogate the functional and therapeutic relevance of a candidate cancer drug target as an essential step towards justifying the subsequent investment in drug discovery efforts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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