Angiotensin II and Oxidative Stress
| Autor: | M. Wendt, T. Münzel, A. Warnholtz, N. Tsilimingas |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species medicine.medical_specialty biology Superoxide medicine.disease_cause medicine.disease Angiotensin II Nitric oxide Nitric oxide synthase chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Endothelial dysfunction Peroxynitrite Oxidative stress |
| Zdroj: | Angiotensin Vol. II ISBN: 9783540406419 |
| DOI: | 10.1007/978-3-642-18497-0_1 |
| Popis: | There is an increasing body of evidence that oxidative stress markedly contributes to endothelial dysfunction and to poor prognosis in patients with coronary artery disease and hypertension. Among many stimuli for oxidative stress in vascular tissue, the role of angiotensin II has been extensively studied. When given acutely, angiotensin II stimulates the release of nitric oxide and activates a nonphagocytic NAD(P)H oxidase, leading to formation of superoxide and of the nitric oxide/superoxide reaction product peroxynitrite. Peroxynitrite in turn may cause tyrosine nitration of prostacyclin synthase and/or oxidation of zinc-thiolate complexes of the nitric oxide synthase associated with inhibition or uncoupling of these enzymes. Further, angiotensin II causes endothelial dysfunction, hypertension, increases the endothelin expression, and inhibition of the cGMP-cGK-I signaling cascade, all of which are secondary to angiotensin II-stimulated production of reactive oxygen species |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|