1393-P: Alterations in the Placental Proteome in Gestational Diabetes

Autor:	Emma Assi, Irene Cetin, Moufida Ben Nasr, Cristian Loretelli, Domenico Corradi, Vera Usuelli, Franco Folli, Francesca Rocchio, Chiara Mandò, Francesca D'Addio, Gian Vincenzo Zuccotti, Anna Maestroni, Paolo Fiorina
Rok vydání:	2019
Předmět:	Gestational diabetes Fetus Pregnancy Metabolic complication business.industry Endocrinology Diabetes and Metabolism Proteome Internal Medicine medicine Fetal growth Physiology medicine.disease business
Zdroj:	Diabetes. 68
ISSN:	1939-327X 0012-1797
Popis:	Gestational diabetes mellitus (GDM) is the most frequent metabolic complication during pregnancy, affecting 3% to 25% women, and it is associated with abnormal fetal growth. Interestingly, the mechanism behind altered fetal growth in GDM is only partially understood. In order to discover novel factors that may play a role in placental function and fetal development, we interrogated the placental proteomes of healthy (CTRL, n=5) and GDM-affected (n=5) pregnant women using an unbiased proteomic approach. We demonstrated that the placental proteome is altered in GDM, with at least 64 proteins differentially expressed to a high degree (p Disclosure E. Assi: None. F. D'Addio: None. M. Ben Nasr: None. C. Loretelli: None. A. Maestroni: None. V. Usuelli: None. C. Mandò: None. F. Rocchio: None. D. Corradi: None. F. Folli: None. G. Zuccotti: None. I. Cetin: None. P. Fiorina: None.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9bffe6ab973ee35fcb07cef4bc04af39 https://doi.org/10.2337/db19-1393-p Zobrazit plný text záznamu