ChemInform Abstract: Polyketides from the Mangrove-Derived Endophytic Fungus Acremonium strictum

Autor:	Abdessamad Debbab, Lena Hammerschmidt, Peter Proksch, Amal H. Aly, Heike Broetz‐Oesterhelt, Tu Duong Ngoc, Matthias U. Kassack, Catalina Perez Hemphil, Victor Wray, Wenhan Lin
Rok vydání:	2014
Předmět:	biology Chemistry Stereochemistry Acremonium strictum Ms analysis General Medicine Endophytic fungus biology.organism_classification medicine.disease_cause Rhizophora apiculata Polyketide Staphylococcus aureus medicine Mangrove Antibacterial activity
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201447234
Popis:	Five new polyketide derivatives, 6′-hydroxypestalotiopsone C ( 1 ), acropyrone ( 2 ), bicytosporone D ( 3 ), waol acid ( 4 ), and pestalotiopene C ( 5 ), together with seven known metabolites ( 6 – 12 ), were obtained from extracts of the endophytic fungus Acremonium strictum , isolated from the mangrove tree Rhizophora apiculata . The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6 , 7 , and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC 50 values 27.1, 76.2, and 8.3 μM, respectively) and resistant A2780 cell lines (IC 50 values 12.6, 30.1, and 19.0 μM, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3 μM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9bfd6dac8cbe5483280a72a56e22c68c https://doi.org/10.1002/chin.201447234 Zobrazit plný text záznamu Plný text