Prenatal ethanol exposure: Correlation of neurobehavioral changes with mother's blood ethanol level

Autor:	Sikta Pradhan, Felicia Briggs, Don Philips
Rok vydání:	1988
Předmět:	medicine.medical_specialty Pregnancy business.industry Offspring Fetal alcohol syndrome Gestation period medicine.disease Endocrinology Neurochemical Oral administration Internal medicine Drug Discovery Toxicity medicine Gestation business
Zdroj:	Drug Development Research. 12:287-296
ISSN:	1098-2299 0272-4391
DOI:	10.1002/ddr.430120312
Popis:	Different liquid diets were tested as vehicles for ethanol administration in order to maximize the blood ethanol level (BEL) in rats. This was done since maternal BEL during the gestation period is believed to be the determining factor for behavioral and neurochemical changes in the offspring. A comparative study with three different liquid diets indicated that the Sustacal and Lieber-DeCarli diets were more effective in elevating the BEL than the Bio-Mix diet. Furthermore, it was observed that prenatal ethanol exposure affected to a varying extent the neuromuscular abilities (detected by rotarod test) and maze-learning in the offspring of mothers that receive ethanol through Lieber-DeCarli diet. No significant (P < 0.01) behavioral changes were observed in the offspring of mothers that received the Bio-Mix diet containing ethanol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9bf6f4335fa9262afe1211e253e3a209 https://doi.org/10.1002/ddr.430120312 Zobrazit plný text záznamu Plný text