451 A Clinical Prediction Model for Histological Chorioamnionitis at Birth

Autor:	Boris W. Kramer, R.R. de Krijger, Jasper V Been, René F. Kornelisse, Ingrid G I J G Rours, Luc J. I. Zimmermann
Rok vydání:	2010
Předmět:	medicine.medical_specialty Fetus Receiver operating characteristic Obstetrics business.industry Singleton Gestational age medicine.disease Logistic regression Chorioamnionitis Preeclampsia Pediatrics Perinatology and Child Health medicine Small for gestational age business
Zdroj:	Pediatric Research. 68:231-232
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-201011001-00451
Popis:	Background: Antenatal exposure to histological chorioamnionitis affects neonatal outcome. Early identification of affected infants could potentiate early intervention. However, in clinical practice the final results of placental pathology may take weeks. Methods: Placental pathology and relevant clinical data were obtained from consecutively born singleton infants (gestational age < 32 wks) in the Erasmus MC. Prediction models for histological chorioamnionitis (HC) and for HC with fetal involvement (FI) were constructed using clinical variables known at birth, in a backward logistic regression model. ROC curves were computed using model-derived predictives. Results: Of the 216 included infants 84 had HC, of whom 51 had FI. HC+FI was best predicted by a combination of low gestational age, clinical chorioamnionitis, PPROM, absence of preeclampsia and not being small for gestational age (Table 1; AUC(95%CI)=0.93(0.89-0.96), p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9bf39738bd89fa088c8cb6f6898b0c37 https://doi.org/10.1203/00006450-201011001-00451 Zobrazit plný text záznamu