Preparative HPLC of an Experimental Anti-HIV Analogue of AZT: Azidothymidine Monophosphate Diglyceride (AZT-MP-DG)
| Autor: | Raj K. Sehgal, Joseph G. Turcotte, Prabha Painuly |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Preparative hplc Chromatography Chemistry Anti hiv viruses virus diseases Fatty acid biochemical phenomena metabolism and nutrition Chemical synthesis High-performance liquid chromatography Zidovudine chemistry.chemical_compound immune system diseases medicine Molecular Medicine heterocyclic compounds Diglyceride medicine.drug Conjugate |
| Zdroj: | Journal of Liquid Chromatography. 16:2237-2248 |
| ISSN: | 0148-3919 |
| Popis: | Monophosphate diglyceride conjugate of AZT containing esterified saturated palmitoyl and unsaturated oleoyl fatty acid, a composition which more closely mimics the natural state (AZT-MP-DG). was synthesized. The purification of AZT-MP-DG from crude synthetic mixture by preparative HPLC is described herein. The practical and rapid chromatographic method developed should be applicable to the purification of structurally related antimetabolic lyponucleotides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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