NEURAL REACTIVITY TO REWARD AS A PREDICTOR OF COGNITIVE BEHAVIORAL THERAPY RESPONSE IN ANXIETY AND DEPRESSION
| Autor: | Stewart A. Shankman, K. Luan Phan, Scott A. Langenecker, Amy E. Kennedy, Katie L. Burkhouse, Autumn Kujawa, Heide Klumpp |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Poison control medicine.disease behavioral disciplines and activities Comorbidity 030227 psychiatry Cognitive behavioral therapy 03 medical and health sciences Psychiatry and Mental health Clinical Psychology 0302 clinical medicine Event-related potential Severity of illness Cognitive therapy medicine Anxiety medicine.symptom Psychology Psychiatry 030217 neurology & neurosurgery Depression (differential diagnoses) Clinical psychology |
| Zdroj: | Depression and Anxiety. 33:281-288 |
| ISSN: | 1091-4269 |
| Popis: | BACKGROUND: Cognitive behavioral therapy (CBT) is a well-established treatment for anxiety and depression; however, response to CBT is heterogeneous across patients and many remain symptomatic after therapy, raising the need to identify prospective predictors for treatment planning. Altered neural processing of reward has been implicated in both depression and anxiety, and improving hedonic capacity is a goal of CBT. However, little is known about how neural response to reward relates to CBT outcomes in depression and anxiety. The current study used the reward positivity (RewP) event-related potential (ERP) component to examine whether neural reactivity to reward would predict CBT response in a sample of patients with anxiety without depression (n = 30) and comorbid anxiety and depression (CAD, n = 22). METHODS: Participants completed a guessing reward ERP paradigm before completing 12 weeks of standard CBT. RESULTS: The majority of the sample (68%; 35 out of 52 patients) responded to treatment, and those with a reduced RewP at baseline were more likely to respond to treatment. A reduced RewP was also associated with a greater pre-to-post CBT reduction in depressive symptoms among individuals with CAD, but not among individuals with pure anxiety. CONCLUSIONS: CBT may be most beneficial in reducing depressive symptoms for individuals who demonstrate decreased reward reactivity prior to treatment. CBT may target reward brain function, leading to greater improvement in symptoms. These effects may be strongest, and therefore most meaningful, for individuals with reward-processing deficits prior to treatment.© 2016 Wiley Periodicals, Inc. Language: en |
| Databáze: | OpenAIRE |
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