A Murine Wilms' Tumor as a Model for Chemotherapy and Radiotherapy 2 3

Autor:	John K. Lattimer, Yves L. Homsy, Myron Tannenbaum, Philip Tomashefsky
Rok vydání:	1976
Předmět:	Oncology Cancer Research medicine.medical_specialty Vincristine Chemotherapy Cyclophosphamide business.industry medicine.medical_treatment Wilms' tumor medicine.disease Chemotherapy regimen Radiation therapy Internal medicine medicine Cancer research Methotrexate Doxorubicin business medicine.drug
Zdroj:	JNCI: Journal of the National Cancer Institute. 56:137-142
ISSN:	1460-2105 0027-8874
Popis:	We studied the effect on tumor volumes and host survival of twenty-four chemotherapeutic and radiotherapeutic regimens in rats bearing the Furth/Columbia murine Wilms' tumor. After 5 years and some 100 transfers, this tumor retained its sensitivity to suitable combinations of actinomycin D, vincristine, and X-ray, regimens in current use in the treatment of human Wilms' tumor. Cytoxan alone was highly inhibitory; adriamycin was modestly inhibitory; and lethal doses of methotrexate followed by leucovorin "rescue" were slightly inhibitory to the growth of the rat tumor. No other chemotherapeutic agent tested was effective by our criteria. Cytoxan, with or without adriamycin, and X-irradiation, were the most useful combinations studied. The chemotherapeutic agents given 3 days before irradiation were significantly more carcinostatic than they were when given after radiotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9bea55e55acdcefe5fc88f227962a2b5 https://doi.org/10.1093/jnci/56.1.137 Zobrazit plný text záznamu