Studies of Rubella
| Autor: | P. D. Parkman, E. L. Buescher, M. S. Artenstein, J. M. McCown, F. K. Mundon, A. D. Druzd |
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| Rok vydání: | 1964 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 93:595-607 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.93.4.595 |
| Popis: | Summary Rubella virus interfered with propagation of enteroviruses, myxoviruses and arboviruses in GMK cultures. Mechanisms involved in production of this interference remain uncertain; no evidence of interferons has been found. Titers of infective rubella virus were measured most accurately by interference in GMK cultures incubated 10 days before challenge. These interference titers were not influenced significantly by specific type of challenge virus or its concentration. Rubella virus strains multiplied in 13 different cell systems including primary, continuous heteroploid and diploid cell lines. Tests in 11 of these showed similar rates of virus growth. Interference, however, developed differently in each culture system and could not be correlated with virus production. The virus was filterable through 300 but not 100 mµ Millipore filters. It was destroyed by heating, ethyl ether, chloroform and formalin. Thermal inactivation rates at 37°C were similar to those to rubeola, herpes simplex and influenza viruses. Propagation was not affected by IDU. No hemagglutinin or complement-fixing antigen has been shown. The findings support the original suggestion that rubella virus is unrelated to other known animal viruses. |
| Databáze: | OpenAIRE |
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