| Autor: |
Hedyeh Javidnia, Marc Carrier, Lionel G. Filion, Rebecca C. Auer, Martin Corsten, Yuhua Li, Adena S Scheer, Mary Hanna, Libni Eapen, David S. Allan |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of Surgical Oncology. 109:151-157 |
| ISSN: |
0022-4790 |
| Popis: |
Introduction:Vascular progenitor cells (VPCs) are recruited into the peripheral blood (PB) following ischemia and inflammation and correlate with vascular health. The impact of recruiting VPCs on surgical recovery and cancer progression following tumor resection remain unknown. Methods: We measured VPC clusters and enumerated circulating CD34þ VEGFR2þ angiogenic cells in 18 patients with oral cancer (OC) undergoing resection and free flap reconstruction (high vascular injury) and in 18 patients undergoing colorectal cancer resection (CRC) (low vascular injury) at baseline and multiple timepoints after surgery. Results: VPC clusters increased following OC resection, peaking on Day þ3 and returning to baseline by Day 28. In contrast, VPC clusters decreasedsharply onDay þ3 in patients withCRCbefore returningto baseline. CD34þVEGFR2þcellsdid not increase significantly after surgery. MorerapidclinicalrecoveryfollowingOCresectionwasobservedinpatientswithgreaterVPCclusterlevelsonDay þ3.Tumorsizeandsubsequent progression of cancer did not correlate with recruitment of VPC cluster‐forming cells. Conclusion: VPC recruitment following cancer resection may depend on cancer subtype and may relate to the degree of surgical stress and vascular injury. Recovery after surgery for OC may be accelerated in patients with greater VPC recruitment. J. Surg. Oncol. 2014;109:151–157. 2013 Wiley Periodicals, Inc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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