Synthesis of Nucleosides with 2′-Fixed Lipid Anchors and Their Behavior in Phospholipid Membranes

Autor:	Ludwig Löser, Jiirgen Liebscher, Andreas Bunge, Anna Arbuzova, Oliver Kaczmarek, Nicolai Brodersen, Andreas Herrmann, Daniel Huster
Rok vydání:	2008
Předmět:	Stereochemistry Vesicle Organic Chemistry Phospholipid Synthesis of nucleosides Membrane anchoring chemistry.chemical_compound Membrane chemistry Amphiphile Molecule Organic chemistry Physical and Theoretical Chemistry POPC
Zdroj:	European Journal of Organic Chemistry. 2008:1917-1928
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200701064
Popis:	Various new nucleosides bearing one or two lipophilic groups at the 2′-position have been synthesized. The lipophilic substituents were attached to a 2′-hydroxy, 2′-amino, or 2′-thio function. These lipophilic nucleosides anchor in large unilamellar POPC vesicles serving as phospholipid membrane models. The insertion of these molecules into the membranes was investigated by NMR techniques. For comparison, nucleosides with two or three lipophilic groups at the 2′-, 3′-, or 5′-positions have also been studied.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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