Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association with Clinical Laboratory Routine Tests
| Autor: | Seyed Reza Raeeskarami, Tooba Ghazanfari, Jalil Arabkheradmand, Reza Najafizadeh, Saba Beiranvand, Sara Ghaffarpour, Mohammad Mehdi Naghizadeh, Azin Roomi, Ensie Sadat Mirsharif, Elahe Baharvand, Davoud Jamali, Mohammad Reza Sattarian, Maedeh Mahmoodi Aliabadi, Samira Jafarpour, Abdolrahman Rostamian, Maryam Rajabnia Chenary, Shafieh Movasseghi, Elham Nezhadseifi, Maryam Edalatifard, Mohammad Salehi, Sajjad Hosseinieselki Sari |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Immunoregulation. :29-36 |
| ISSN: | 2588-6088 2588-5200 |
| DOI: | 10.32598/immunoregulation.3.1.4 |
| Popis: | Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients. Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests. Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P |
| Databáze: | OpenAIRE |
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