| Autor: |
N. M. Argôlo Neto, R.J. Del Carlo, A. F. S. de Brito, Pedro Cesar Chagastelles, Amanda Maria S. Reis, B. S Monteiro, Nance Beyer Nardi |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Clinical and Experimental Dermatology. 37:544-553 |
| ISSN: |
0307-6938 |
| Popis: |
Summary Background. Chronic cutaneous lesions affect 15% of human patients with diabetes, and the associated risk of limb amputations is 15–46 times greater than that of people with normal glycaemia. It is estimated that half of these limb amputations could be avoided by opportune treatment with somatic stem cells or platelet-rich plasma (PRP). Methods. We evaluated the effects of autologous transplant of mesenchymal stem cells (MSCs) with or without combination with autologous PRP in the re-epithelialization of cutaneous lesions induced in diabetic mice. Results. Animals treated with MSCs alone showed a similar level of re-epithelialization of cutaneous lesions to those treated with MSC plus PRP, and no significant difference was found between the two treatments. Conclusion. Both treatments gave better results than daily cleaning of the cutaneous lesions with saline or covering of the lesions with semipermeable adherent bandage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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