Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)

Autor: Magda F. Mohamed, Nada S. Ibrahim, Amna A. Saddiq, Omar A. Almaghrabi, Maha E. Al-Hazemi, Hamdi M. Hassaneen, Ismail A. Abdelhamid
Rok vydání: 2022
Předmět:
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology. 396:719-736
ISSN: 1432-1912
0028-1298
Popis: A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line.
Databáze: OpenAIRE
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