Rothtalazepane, A New Azepane from the Wood of Rothmannia talbotii (Rubiaceae)
| Autor: | Serge A.T. Fobofou, Ingrid Simo Konga, Jean De Dieu Tamokou, Ludger A. Wessjohann, Romeol Romain Koagne, Gabin Thierry M. Bitchagno, Pierre Tane |
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| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Rubiaceae biology Traditional medicine 010405 organic chemistry Plant Science General Medicine biology.organism_classification 01 natural sciences 0104 chemical sciences Rothmannia 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Azepane chemistry Drug Discovery |
| Zdroj: | Natural Product Communications. 12:1934578X1701200 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1701200912 |
| Popis: | Rothmannia talbotii, a hitherto chemically unexplored medicinal plant, is used in the Western Region of Cameroon to relieve fever. In our ongoing search for bioactive compounds from Cameroonian medicinal plants, a previously undescribed compound rothtalazepane (1), along with six known compounds, aitchisonide B (2), D-mannitol (3), β-D-glucopyranosyl-(6→1’)-β-D-glucopyranoside (4), monopalmitin (5), stigmasterol (6), and sitosterol 3- O-β-D-glucopyranoside (7) were isolated and characterized from the crude ethanol extract of the wood of R. talbotii. Rothtalazepane (1) exhibits no significant activity against several microbial strains, thus its function likely lies not in antimicrobial defense and it is not the active principle against urinary infections described for Rothmannia. |
| Databáze: | OpenAIRE |
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