Use of nonsteroidal anti-inflammatory drugs prior to chronic renal replacement therapy initiation: a nationwide study
| Autor: | Søren Lund Kristensen, Lars Køber, Christian Torp-Pedersen, Kristine Hommel, Emil L. Fosbøl, Morten Lamberts, Thalia Marie Blicher, Anne-Lise Kamper, Steen Zabell Abildstrøm, Gunnar Gislason |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Epidemiology business.industry medicine.medical_treatment Interstitial nephritis Renal function Pharmacoepidemiology urologic and male genital diseases medicine.disease Comorbidity Surgery Transplantation Internal medicine medicine Pharmacology (medical) Renal replacement therapy business Dialysis Kidney disease |
| Zdroj: | Pharmacoepidemiology and Drug Safety. 21:428-434 |
| ISSN: | 1053-8569 |
| DOI: | 10.1002/pds.3227 |
| Popis: | Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use, aetiology and comorbidity among a national cohort of patients before the initiation of chronic renal replacement therapy (RRT). Methods Patients initiated on chronic RRT in the period 1997–2006 were identified in the Danish National Registry on Regular Dialysis and Transplantation, including etiological diagnosis. The use of NSAID before the start of RRT was studied by linkage to the National Prescription Register and comorbidity by linkage to the National Patient Registry. Results A total of 6663 patients were included in the study, and 2407 patients (36.1%) were prescribed NSAID in the 3 years before the start of RRT. These patients were older (mean age = 63.0 vs 61.4 years) and had a significantly higher degree of comorbidity (Charlson score = 2.85 vs 2.61, p |
| Databáze: | OpenAIRE |
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