CMV Immunity Status in Older (>50 Years Old) Subjects after Non-Myeloablative or Reduced Intensity Regimen for Hematopoietic Cell Transplantation (HCT): A Comparison with a Younger Cohort after Ablative HCT
| Autor: | Joybelle Martinez, Simon F. Lacey, Don J. Diamond, Ryotaro Nakamura, Anne E. Franck, Norma A. Lomeli, Xiuli Li, Ghislaine Gallez-Hawkins, Lia Thao, John A. Zaia, Stephen J. Forman, Ricardo Spielberger |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Blood. 106:3246-3246 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Immunity declines with age as demonstrated by cell-mediated and humoral responses to alloantigens. The susceptibility of these elderly subjects to endogenous virus infection, such as human cytomegalovirus (HCMV) reactivation, is a particular concern during the process of hematopoietic stem cell transplantation (HCT) and immune reconstitution. In this report, the host contribution to stem cell engraftment and differentiation was evaluated by comparing the HCMV immune response in older subjects (> 50 y.o.) to a younger (< 50 y.o.) transplant population. This was a retrospective analysis of a subset of data collected prospectively and with IRB approval for characterization of the CMV immune response of allogeneic transplant patients. Within the dataset, two groups of patients were compared. Group 1 consisted of 10 patients >50 y.o. who had received reduced intensity or non-myeloablative conditioning regimen, and Group 2 consisted of 13 patients |
| Databáze: | OpenAIRE |
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