Structure-Function and Pathogenesis Studies of Streptococcus pyogenes Extracellular Cysteine Protease

Autor:	James M. Musser, Eugene H. Burns, Ann Marie Marciel
Rok vydání:	1997
Předmět:	Endothelial stem cell Chemistry Zymogen Streptococcus pyogenes medicine Extracellular Collagenase Gelatinase medicine.disease_cause Cysteine protease Microbiology Cysteine medicine.drug
Zdroj:	Streptococci and the Host ISBN: 9781489918277
DOI:	10.1007/978-1-4899-1825-3_136
Popis:	Replacement of the single cysteine residue (C192) with serine in the Streptococcus pyogenes extracellular cysteine protease (SCP) prevented auto-catalytic processing of the 40-kDa zymogen to the 28-kDa mature form and eliminated proteolytic activity. SCP incubated with human endothelial cells induced a time- and concentration-dependent increase in a 66-kDa gelatinase/type IV collagenase in culture supernatants. Activation of this gelatinase/collagenase may contribute to endothelial cell damage, tissue destruction, and hemodynamic derangement observed in some patients with severe, invasive S. pyogenes infection.
Databáze:	OpenAIRE
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