Parietal Cell Hyperplasia Induced by the Administration of Pentagastrin (ICI 50,123) to Rats
| Autor: | R.D.E. Rumsey, G.P. Crean, M.W. Marshall |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Hepatology business.industry Stomach Peptic digestive oral and skin physiology Population Gastroenterology Hyperplasia medicine.disease Pentagastrin chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Gastric mucosa education business hormones hormone substitutes and hormone antagonists Histamine Parietal cell medicine.drug |
| Zdroj: | Gastroenterology. 57:147-155 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(19)33930-7 |
| Popis: | Pentagastrin (Peptavlon, ICI 50,123, 4 mg per day for 21 days) and histamine (12 mg of base per day for 21 days) were administered in depot form to rats equipped with chronic gastric fistulas. The administration of pentagastrin led to a 4-fold increase in acid output, and caused increases in the height of the fundic mucosa, in the average count of parietal cells per unit area of the mucosa, and in the total parietal cell population of the stomach. Histamine caused a 2-fold increase in acid secretion, but exerted no effects on the gastric mucosa. The peptic cell population was not affected by either form of treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|