Role of IL-23 gene expression in development of psoriatic arthritis among psoriasis patients
| Autor: | Zainab Sabeeh Al-Hwas, Naael H Ali, Khalel Ismael Al-Hamdi, Zainab A Mahmood |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :14498-14507 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns2.8797 |
| Popis: | Background: Psoriasis (PS) is an inflammatory skin disorder that lasts for a long time. About 30% of peoples with psoriatic arthritis and characterized as inflammatory arthritis that affects joints or entheses. Although there is growing evidence that interleukin-23 is a kind of interleukin that is produced by (IL-23) Signaling is important in the pathophysiology of both PS and PsA, it is unclear whether IL-23-induced skin inflammation causes joint disease. The goal of this research is to determine the expression of genes (IL-23) in PsA patients in Basrah. Material and Methods: The current study included 88 participants, 59 of whom had Poraisis (Ps), 29 of whom had Psoriatic arthritis, and 40 healthy controls (HC). From August 2020 to February 2022, samples were collected from patients at Al-Sadar Teaching Hospital and Basrah Teaching Hospital's Rheumatology Unite and Biological Therapy Center. Total RNA was collected from peripheral blood and used to evaluate the expression of the genes of interest using qRT-PCR. Results: The binding of the SYBR green dye was unique to the target genes through one peak in the melting curve data and amplification curve for the genes of interest, which included IL-23. |
| Databáze: | OpenAIRE |
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