DJK-5 incorporated porous titanium alloy with combined superior antibacterial efficacy and enhanced osteoblastic cell responses
| Autor: | Yao Wang, Jing He, Fang Wu, Junwei Zhang, Tao Gao, Nihui Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Materials science Cytoskeleton organization Mechanical Engineering Alloy Peptide 02 engineering and technology Antibacterial efficacy engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Osteoblastic cell 01 natural sciences 0104 chemical sciences chemistry Mechanics of Materials Highly porous engineering Biophysics General Materials Science 0210 nano-technology Cell adhesion Porous titanium |
| Zdroj: | Materials Letters. 251:161-164 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2019.05.046 |
| Popis: | Osteogenic activity is an indispensible factor that has to be considered when designing antibacterial surfaces for orthopaedic applications. To this aim, a novel DJK-5 peptide was successfully incorporated on a highly porous Ti alloy coating, through the aid of self-polymerization of dopamine. The modified surface demonstrated superior broad spectrum antibacterial efficacy against S. aureus, S. epidermidis and P. aeruginosa, respectively. Simultaneously, the incorporation of DJK-5 peptide stimulated the osteoblastic cell responses, by promoting both cell adhesion and cytoskeleton organization of MC3T3-E1 cells. Such findings would have important implication in designing implant surfaces with both antibacterial efficacy and enhanced osseo-integration potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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