Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result

Autor:	A. I. A. Hamid, Mar Husbani, J M Shuhada, AR Muhammad
Rok vydání:	2020
Předmět:	Epilepsy medicine.medical_specialty nervous system business.industry Healthy subjects Medicine Audiology business medicine.disease behavioral disciplines and activities Default mode network Temporal lobe
Zdroj:	IOP Conference Series: Materials Science and Engineering. 785:012047
ISSN:	1757-899X 1757-8981
DOI:	10.1088/1757-899x/785/1/012047
Popis:	The default mode network (DMN) is thought to be impaired in epileptic patients, where the functional integrity of its core regions compromised. Fourteen healthy participants and fourteen aged and gender-matched patients with temporal lobe epilepsy (TLE) took part in this study. The resting-state fMRI (rsfMRI) imaging protocol was executed using a 3-T Phillips Achieva MRI scanner at the Department of Radiology, HUSM. The TLE patient displays decreased activation clusters in precuneus and supramarginal gyrus compared to the healthy group. However increased activation clusters were found on middle frontal gyrus, superior temporal gyrus, and angular gyrus compared to healthy subjects. The result from random effects (RFX) on healthy TLE revealed that the left middle frontal gyrus, bilateral superior temporal gyrus, bilateral precuneus, and right supramarginal gyrus were significantly activated but the NOV survive was so small. The findings suggested that TLE patients suffer from impairment in some DMN region, which may cause certain neuropsychological and cognitive degradation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9b6ccd12bc5d3e8ac302bb8f114e8fc0 https://doi.org/10.1088/1757-899x/785/1/012047 Zobrazit plný text záznamu