Hormonal Regulation of Hyaluronidase during Spermatogenesis in the Rat
| Autor: | Roger W. Turkington, James L. Males |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Germinal epithelium
endocrine system medicine.medical_specialty Hypophysectomy Spermatid medicine.medical_treatment Cell Biology Biology Biochemistry Endocrinology medicine.anatomical_structure Hyaluronidase Internal medicine medicine Luteinizing hormone Molecular Biology Spermatogenesis Testosterone medicine.drug Hormone |
| Zdroj: | Journal of Biological Chemistry. 245:6329-6334 |
| ISSN: | 0021-9258 |
| DOI: | 10.1016/s0021-9258(18)62613-4 |
| Popis: | Hyaluronidase activity has been studied during hormone-dependent cell differentiation of the germinal epithelium in the rat testis. Hyaluronidase in rat testis is particulate and sediments with the lysosomal fraction, but can be released by treatment with cetyltrimethylammonium bromide. Rat testicular hyaluronidase activity is undetectable until 33 to 34 days of age, at which time it appears and subsequently increases 400-fold. This rapid increase is correlated with acrosome formation in the newly formed spermatids. Hypophysectomy completely prevents the formation of spermatids and of hyaluronidase, although prolonged treatment of the hypophysectomized rats with luteinizing hormone and follicle-stimulating hormone or with testosterone permits spermatid formation and restores the specific activity of hyaluronidase to normal. Hyaluronidase activity thus appears to represent an accurate biochemical marker for the biological development of testis cells at a specific, hormone-dependent transition in spermatogenesis. |
| Databáze: | OpenAIRE |
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