Substrate influx can modulate the persistence of the active state in hysteretic enzymes: A theoretical analysis

Autor:	B. N. Goldstein, A. M. Aksirov, D. T. Zakrjevskaya
Rok vydání:	2007
Předmět:	Calcium ATPase Hysteresis Membrane chemistry Biochemistry Biophysics Substrate (chemistry) chemistry.chemical_element Plasma Calcium Signal Ion
Zdroj:	Biophysics. 52:327-330
ISSN:	1555-6654 0006-3509
DOI:	10.1134/s0006350907030128
Popis:	A simple kinetic model is proposed for a hysteretic enzyme with an inflow of substrate (or transported ion). There can be two steady states of activity, with an abrupt transition to the lower level. The duration of the first, activated state rather than its height is determined by the effective substrate (ion) concentration, while oscillatory switchover between states is an intrinsic property of hysteretic enzymes. With plasma membrane Ca-ATPase as an example, it is shown that the magnitude of the input calcium signal can be translated into the time span for which the enzyme persists in the activated state.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9b56f0a884c42acd88ff42e8397fb25f https://doi.org/10.1134/s0006350907030128 Zobrazit plný text záznamu Full text from SpringerLink