Progression to end Stage Renal Disease in Poststreptococcal Glomerulonephritis (PSGN) - Chandigarh Study
| Autor: | V N Unni, M.M. Kapoor, Kirpal S. Chugh, Vinay Sakhuja, S.R. Bhusnurmath, Pirzada R, H. S. Malhotra, P C Singhal, Singh N |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
business.industry Urinary system 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering General Medicine Disease 030204 cardiovascular system & hematology urologic and male genital diseases medicine.disease Gastroenterology Uremia End stage renal disease Biomaterials 03 medical and health sciences 0302 clinical medicine Elevated serum creatinine Internal medicine medicine Lost to follow-up Prospective cohort study business Post-streptococcal glomerulonephritis |
| Zdroj: | The International Journal of Artificial Organs. 10:189-194 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139888701000311 |
| Popis: | 193 patients (142 adults and 51 children) with acute PSGN were followed long term. Sixty percent had elevated serum creatinine and 14% had nephrotic range proteinuria at the onset. By two years 28 patients (14%) had died from uremia, and 19 were lost to follow up. Amongst the remainder, 8 patients (4%) had developed mild to moderate renal insufficiency, 12% were hypertensive, and 22% had urinary abnormalities. Of the 146 patients alive at 2 years, 107 were followed up to 10 years (mean 4.8 years). In addition to the 8 patients with renal insufficiency at 2 years, another 7 developed renal failure subsequently. Four out of these 15 patients progressed to uremia within 4 to 10 years after the onset of disease. Hypertension and persistent urinary abnormalities were present in 15% and 24% respectively. Progression to uremia occurred in 6% of children and 20% of adults. Nephrotic range proteinuria, renal insufficiency at the onset, and crescents in more than one third of glomeruli indicated a poor prognosis. |
| Databáze: | OpenAIRE |
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