Foetal and neonatal alloimmune thrombocytopenia (FNAIT)
| Autor: | Bjørn Skogen, Heidi Tiller, T Ahlen, Anne Husebekk, Mariana Eksteen, Jens Kjeldsen-Kragh, Tor B. Stuge, Mette Kjaer Killie |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
Fetus biology business.industry chemical and pharmacologic phenomena medicine.disease Human platelet antigen Anti hpa 1a Immune system Immunization Immunology Neonatal alloimmune thrombocytopenia biology.protein medicine Antibody business hormones hormone substitutes and hormone antagonists |
| Zdroj: | ISBT Science Series. 6:261-264 |
| ISSN: | 1751-2816 |
| DOI: | 10.1111/j.1751-2824.2011.01498.x |
| Popis: | Thrombocytopenia is detected in around one percent of newborns. In otherwise healthy term newborns, thrombocytopenia is most often caused by alloantibodies transferred from the mother to the foetus. In the Caucasian populations human platelet antigen (HPA)-1a is the most immunogenic HPA. In Japan and China antibodies in the HPA-4 system are the most frequent cause of FNAIT. The immune response against the HPA must be understood in order to avoid immunization or prevent induction of FNAIT where mothers are already immunized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text