ChemInform Abstract: Enantio- and Stereospecific Syntheses of 15(R)-Me-PGD2, a Potent and Selective DP2-Receptor Agonist

Autor:	Gail E. Grant, Seongjin Kim, William S. Powell, Pranav Patel, Joshua Rokach, Gue-Jae Lee
Rok vydání:	2009
Předmět:	Agonist medicine.drug_class Chemistry Stereochemistry Synthon Enantioselective synthesis Total synthesis General Medicine Ring (chemistry) Combinatorial chemistry Stereocenter Stereospecificity medicine Salt metathesis reaction
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200904206
Popis:	The first total synthesis of 15(R)-Me-PGD2 3 is reported. The synthesis is based on the enantioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction. This approach permits the introduction of a side chain with a predetermined stereogenic center into the prostanoid ring, resulting in the synthesis of 15R-methyl prostaglandin D2 and allows rapid access to other prostanoids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9b49df2ef9db741b635998f48e28008f https://doi.org/10.1002/chin.200904206 Zobrazit plný text záznamu Plný text