CD62, thromboxane B2, and beta-thromboglobulin: A comparison between different markers of platelet activation after contact with biomaterials
| Autor: | Donatella Granchi, Elisabetta Cenni, S. Gamberini, E. Verri, G. Falsone, D. Cavedagna, Arturo Pizzoferrato |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Biocompatibility Chemistry Biomedical Engineering Biomaterial Radioimmunoassay Flow cytometry Biomaterials Thromboxane B2 chemistry.chemical_compound Endocrinology Biochemistry Beta-thromboglobulin Internal medicine medicine Platelet Platelet activation |
| Zdroj: | Journal of Biomedical Materials Research. 36:289-294 |
| ISSN: | 1097-4636 0021-9304 |
| DOI: | 10.1002/(sici)1097-4636(19970905)36:3<289::aid-jbm3>3.0.co;2-a |
| Popis: | The authors examined the modifications of some markers of platelet activation after contact with biomaterials. Glycoprotein GMP-140 (CD62) was evaluated by flow cytometry; β-thromboglobulin (β-TG) and thromboxane B2 (TXB2) were determined by radioimmunoassay. Polyethylene terephthalate (PET) induced a remarkable platelet adhesion and a significant increase in β-TG and TXB2, with no increase in CD62 on the nonadherent platelets. Pyrolytic carbon-coated PET (PC) did not induce platelet adhesion after 15 min of contact, but a significant increase in CD62 was detected. After 30 min a significant increase in platelet adhesion as well as the release of β-TG and TXB2 were noted. The increase was lower than that observed for uncoated PET, and after 30 min of contact with PC the increase no longer was observed. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 36, 289–294, 1997. |
| Databáze: | OpenAIRE |
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