P150 Identification of features associated with poor outcomes in pediatric patients with ulcerative proctitis: A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN
| Autor: | N Tal-Shifman, C Tzivinikos, M Gasparetto, D E Serban, E Zifman, I Hojsak, O Ledder, A Yerushalmy Feler, H Rolandsdotter, M Aloi, M Bramuzzo, S Buderus, P Lionetti, L Norsa, C Norden, D Urlep, C Romano, R Shaoul, C Martinez-Vinson, A Karoliny, G Veereman, B Kang, E Vlčková, P Alvisi, M Kori, M Tavares, B Weiss, S Hussey, M Essen Qamhawi, L M Palomino Pérez, P Henderson, R Parmar, E Miele, F Firas Rinawi, A Lonzano-Ruf, V Zamvar, K L Kolho, D Shouval |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Crohn's and Colitis. 17:i309-i311 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | Background Ulcerative proctitis (UP) is an uncommon presentation in paediatric patients with ulcerative colitis, accounting for Methods A retrospective cohort study involving 37 sites affiliated with the IBD Interest group of ESPGHAN. Data were collected at different timepoints from patients diagnosed with UP aged Results Two hundred and fifty patients with UP were included, with a median age at diagnosis of 14.5 (IQR 12.3-15.9) years, and a median follow-up of 2.7 (IQR 1.7-3.9) years. The most common presenting symptoms were bloody stools (94%), abdominal pain (59%) and diarrhea (53%). At diagnosis, the median pediatric ulcerative colitis activity index (PUCAI) score was 25 (IQR 20-35), and only 3 patients (1.3%) presented with ASC. Most children had normal inflammatory markers and albumin levels. the median fecal calprotectin level was 720 mcg/g (IQR 310-1800), while 16 patients (9.9%) had a calprotectin level Conclusion Disease burden is significant in paediatric patients that present with UP, with high rates of proximal disease extension and requirement for treatment escalation. |
| Databáze: | OpenAIRE |
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