Immunization of Children With Acute Lymphoblastic Leukemia With Live Attenuated Varicella Vaccine Without Complete Suspension of Chemotherapy

Autor:	Allan M. Arbeter, Linda Granowetter, Stuart E. Starr, Beverly Lange, Robert Wimmer, Stanley A. Plotkin
Rok vydání:	1990
Předmět:	Pediatrics Perinatology and Child Health
Zdroj:	Pediatrics. 85:338-344
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.85.3.338
Popis:	A total of 44 children with acute lymphoblastic leukemia were immunized against chickenpox with the Oka/Merck strain live attenuated varicella vaccine. Of these children, 24 continued oral chemotherapy with 6-mercaptopurine during the immunization period and 20 had suspension of all chemotherapy for 1 week before and 1 week after the vaccine. Seroconversion, as determined by the detection of fluorescent antibody to membrane antigens, occurred in 91% and did not differ between patients continuing 6-mercaptopurine from those in whom chemotherapy was suspended. Fever and/or rash occurred in less than one third of vaccinated children. Unexpected reactions occurred in two vaccinated children, one from each group, both of whom had low absolute lymphocyte counts (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9b25052df161926b27fe8ec9c2aca3b6 https://doi.org/10.1542/peds.85.3.338 Zobrazit plný text záznamu