Acute Myeloid Leukemia With Monosomal Karyotype

Autor:	Olga K. Weinberg, Athena M. Cherry, Li Ren, Robert S. Ohgami, Mahesh Seetharam, Daniel A. Arber, Jason Gotlib, Lisa Ma, Katie Seo
Rok vydání:	2014
Předmět:	Oncology medicine.medical_specialty NPM1 Pathology Autosome CD34 Myeloid leukemia Retrospective cohort study General Medicine Biology medicine.disease medicine.anatomical_structure Dysplasia hemic and lymphatic diseases Internal medicine Complex Karyotype medicine Bone marrow neoplasms
Zdroj:	American Journal of Clinical Pathology. 142:190-195
ISSN:	1943-7722 0002-9173
Popis:	Objectives: Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype. Methods: In this retrospective study of 111 patients with AML, we identified 14 patients with MK (13% of all patients with AML) using the definition proposed by Breems et al. Results: Five (36%) of these 14 patients had a loss of a single chromosome in the presence of other structural abnormalities, and nine (64%) had a loss of two or more autosomal chromosomes. Patients with AML-MK presented at an older age, with lower bone marrow blasts, and their blasts less frequently expressed CD34. Most patients with AML-MK had morphologic multilineage dysplasia and were predominantly subclassified as having AML with myelodysplasia-related changes (AML-MRC). Molecular analysis showed a significant absence of NPM1 and FLT3 in patients with AML-MK. Conclusions: Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9b23d159ab3c6244fe46c294bf8a999d https://doi.org/10.1309/ajcpmlo84jdnvlnk Zobrazit plný text záznamu