Genotypic relative risks under ordered restriction

Autor: David Clayton, M. N. Chiano
Rok vydání: 1998
Předmět:
Zdroj: Genetic Epidemiology. 15:135-146
ISSN: 1098-2272
0741-0395
DOI: 10.1002/(sici)1098-2272(1998)15:2<135::aid-gepi3>3.0.co;2-5
Popis: In mapping diseases of complex aetiology, conventional linkage approaches narrow the location of the disease susceptibility locus to quite a large region so that candidate gene association studies are then necessary to further isolate these genes. However, even in the simplest scenario where the candidate locus is bi-allelic, two statistical tests with various correcting factors have been proposed: a chi-square 1 df test (counting chromosomes) which may be slightly conservative and a 2 df chi-square test (counting genotypes) which may lack power because of the extra degree of freedom. This paper introduces a better and more powerful alternative which turns out to be a compromise between the two existing statistical tests. The asymptotic distribution of this test statistic is determined and the efficacy of the 3 tests are compared under different genetic models by simulation.
Databáze: OpenAIRE
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