Microwave-assisted green synthesis, antimicrobial activity, and drug-likeness of novel isoindolinone derivatives
| Autor: | Ahmed Majeed Jassem, Adil Muala Dhumad |
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| Rok vydání: | 2020 |
| Předmět: |
biology
010405 organic chemistry Decarboxylation Aspergillus niger General Chemistry Bacillus subtilis 010402 general chemistry Antimicrobial biology.organism_classification 01 natural sciences Environmentally friendly Combinatorial chemistry 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Fusarium oxysporum Cetrimonium bromide |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 151:1433-1442 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-020-02661-y |
| Popis: | An efficient and green microwave method has been developed for the synthesis of novel isoindolinone derivatives with good yields. The framework of these derivatives was constructed from β-ketocarboxylic acids, various primary amines, and 2-carboxybenzaldehyde via cetrimonium bromide salt-promoted multicomponent cascade of decarboxylation/lactamization reaction. This methodology features a simple, environmentally friendly approach, employing water as a green solvent and using a one-pot, three-component reaction. The synthesized compounds were evaluated for their antimicrobial activity in vitro against six microorganisms, namely Escherichia coli, Serratia, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and Fusarium oxysporum. The results revealed that these derivatives have a significant antimicrobial activity. In addition, the drug-likeness of these derivatives has been evaluated. |
| Databáze: | OpenAIRE |
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