Development of microbial resistant thermosensitive Ag nanocomposite (gelatin) hydrogels via green process
| Autor: | Konduru Mohana Raju, B. Manjula, Kokkarachedu Varaprasad, G. Venkata Subba Reddy, Rotimi Sadiku, Koduri Ramam |
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| Rok vydání: | 2013 |
| Předmět: |
Biodegradable hydrogels
Materials science food.ingredient Nanocomposite biology technology industry and agriculture Metals and Alloys Biomedical Engineering Nanoparticle macromolecular substances Azadirachta biology.organism_classification complex mixtures Gelatin Silver nanoparticle Biomaterials food Chemical engineering Self-healing hydrogels Polymer chemistry Ceramics and Composites medicine Swelling medicine.symptom |
| Zdroj: | Journal of Biomedical Materials Research Part A. 102:928-934 |
| ISSN: | 1549-3296 |
| DOI: | 10.1002/jbm.a.34780 |
| Popis: | In this investigation, an ecofriendly method for the synthesis of silver nanoparticles (AgNPs) using biodegradable gelatin as a stabilizing agent is reported. Here, we prepared thermosensitive silver nanocomposite hydrogels composed of gelatin and N-isopropylacrylamide. In this green process AgNPs were formed from Ag(+) ions and reduced with leaf [Azadirachta indica (neem leaf)] extracts, resulting in a hydrogel network. The Ag(0) nanoparticles affect the hydrogel strength and improved the biological activity (inactivation effect of bacteria) of the biodegradable hydrogels. The resulted hydrogel structure, morphology, thermal, swelling behavior, degradation, and antibacterial properties were systematically investigated. The biodegradable thermosensitive silver nanocomposite hydrogels developed were tested for antibacterial activities. The results indicate that these biodegradable silver nanocomposite hydrogels are suitable potential candidates for antibacterial applications. |
| Databáze: | OpenAIRE |
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