| Autor: |
S. O. Agunbiade, Daramola Ot, Okonko Io, K. C. Anugweje |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Frontiers in Science. 2:127-132 |
| ISSN: |
2166-6083 |
| DOI: |
10.5923/j.fs.20120205.05 |
| Popis: |
Neuroto xicity tests in animals exposed to toxic substances could provide additional informat ion on possible neurotoxic effects. The aim o f this study is to determine the nephrotoxic effect of wastewater discharged fro m a carbonaceous industry on mice (Mus musculus). The present study examined the nephrotoxic effects of carbonaceous wastewater in mice, the mice were exposed to five different concentrations of the waste water. Cyclophosphomide was used as the positive control and distilled water was used as a negative control, for a period of 35das. Creatinine and urea concentration in seru m was used as kidney function. The weights of the animals were recorded weekly after which their kidneys were harvested. Organ weight was measured at post exposure and preserved afterwards for histology. The physical, chemical and heavy metal co mposition of the wastewater was also analysed. There was no significant (P>0.05) change in the kidney and body weight of the exposed mice or the negative control. The activities of urea and creatinine in the serum of exposed mice were significantly increased co mpared to the negative control mice and this increase was concentration dependent at P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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