Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study
| Autor: | Jeffrey J. Kim, Bagrat Grigoryan, Brandi Braud Scully, Charles D. Fraser, K. J. Grande-Allen, G. W. Vick, Christopher Fan, David L.S. Morales, Jeffrey G. Jacot |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Biomedical Engineering 02 engineering and technology 030204 cardiovascular system & hematology 021001 nanoscience & nanotechnology medicine.disease Biomaterials Neovascularization Extracellular matrix 03 medical and health sciences 0302 clinical medicine Intestinal mucosa In vivo Optical mapping medicine Myocyte Immunohistochemistry medicine.symptom 0210 nano-technology Calcification Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 104:1713-1720 |
| ISSN: | 1552-4973 |
| DOI: | 10.1002/jbm.b.33484 |
| Popis: | Background Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa-derived extracellular matrix (ECM) have biological remodeling potential. This pilot study investigated histological, mechanical, and bioelectrical properties of an ECM patch implanted in the ovine right-ventricular outflow tract (RVOT). Materials and Methods ECM patches (2 × 2 cm2) were implanted in four Western Range sheep (wether males, 37–49 kg, age |
| Databáze: | OpenAIRE |
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