Impact of adjuvant therapy toxicity on quality of life and emotional symptoms in patients with colon cancer: a latent class analysis
| Autor: | Alberto Carmona-Bayonas, Paula Jiménez-Fonseca, Caterina Calderon, R Martinez Cabañez, D Gomez, María del Mar Muñoz, D. Cacho Lavín |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty business.industry Colorectal cancer Cancer General Medicine medicine.disease humanities Latent class model 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Quality of life 030220 oncology & carcinogenesis Internal medicine Toxicity Adjuvant therapy Medicine business Adverse effect Somatization |
| Zdroj: | Clinical and Translational Oncology. 23:657-662 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-020-02454-z |
| Popis: | To identify distinct trajectories of toxicity in colorectal cancer (CRC) patients after adjuvant chemotherapy and its impact on quality of life (QoL) and psychological symptoms. A prospective, multicenter study was conducted in 157 patients. A latent class analysis defined the unobserved latent constructs that can be predicted as symptom clusters, considering the intensity of four types of adverse events (AEs). Patients completed EORTC-QLQ-C30, BSI-18, PDRQ-9, and DRS scales. Ninety-six percent had some degree of toxicity, with grades 3–4 being the most common: neurotoxicity (7.2%), hematological (13.1%), digestive (5.2%), and skin toxicity (1.4%). Three distinct latent classes were identified (high [72.5%], mild [16.9%], and low [10.6%] toxicity). Patients with high toxicity had the worst QoL scores and moderately high somatization and psychological distress scores. Adjuvant chemotherapy for CRC was associated with frequent toxicity that negatively impacted QoL and psychological wellbeing. |
| Databáze: | OpenAIRE |
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