Direct separation of carboxylic acid and amine enantiomers by high-performance liquid chromatography on reversed-phase silica gels coated with chiral copper(II) complexes
| Autor: | Hajimu Kitahara, Naobumi Ôi, Fumiko Aoki |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Chromatography Chemistry Carboxylic acid Organic Chemistry Penicillamine chemistry.chemical_element General Medicine Biochemistry High-performance liquid chromatography Copper Capacity factor Analytical Chemistry Phase (matter) medicine Amine gas treating Enantiomer medicine.drug |
| Zdroj: | Journal of Chromatography A. 707:380-383 |
| ISSN: | 0021-9673 |
| Popis: | Excellent direct separation of various carboxylic acid and amine enentiomers was accomplished by HPLC on reversed-phase silica gels coated with copper(II) complexes of N,S-dioctyl- d -penicillamine and ( R , R )-tartaric acid mono-( R )-1-( α -naphthyl)ethylamide. The chiral recognition mechanism is discussed. These copper(II) complexes are promising as chiral stationary phases for the separation of a variety of racemic carboxylic acids and amines in which copper(II) complex formation can be assumed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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