Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications

Autor:	Bo Wang, Ai-Yun Peng, Hanyu Chu, Zecai Xiao, Xunwei Chen
Rok vydání:	2018
Předmět:	chemistry 010405 organic chemistry Organic Chemistry chemistry.chemical_element Organic chemistry Physical and Theoretical Chemistry 010402 general chemistry Iodine 01 natural sciences Biochemistry 0104 chemical sciences Open air
Zdroj:	Organic & Biomolecular Chemistry. 16:6783-6790
ISSN:	1477-0539 1477-0520
Popis:	A systematic study on the iodine-mediated phosphoramidation reaction of amines and trialkyl phosphites was conducted, which not only disclosed the factors affecting the reaction but also revealed that it could proceed smoothly in CH2Cl2 at room temperature in open air. Using this method, various phosphoramidates with different aliphatic amines and aromatic amines were synthesized in good to excellent yields. Our present investigation shows that this underused method is actually a mild, practical and general way to synthesize phosphoramidates and will have wide applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9afb610cb7cfc320cf1a60e415771db4 https://doi.org/10.1039/c8ob01840e Zobrazit plný text záznamu