Keto C-glycosides. a new class of antitumor compounds

Autor:	Kostas Antonakis, Jean Herscovici, Charles Frayssinet, M. Idriss Bennani-Baiti
Rok vydání:	1991
Předmět:	C glycosides Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry chemistry.chemical_compound Aglycone chemistry Drug Discovery Molecular Medicine Organic chemistry Cytotoxic T cell Methylene Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 1:395-398
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80263-2
Popis:	A series of 4-keto unsaturated C-glycosided was synthesized from O-acetyl C-glycosides. These compounds and some parent 2-keto unsaturated C-glycosides were tested for cytotoxic activity against LFCl 2 A cells (Rat hepatocarcinoma cells). C-Glycosides with an acyclic aglycone have not been found cyctotoxic, whereas 1-methyl cyclohexenyl and methylene cyclohexenyl C-glycosides possessed IC 50 values of 9-0.03 μM with 11 being the most potent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9aee40767cd914b2f9222049631586d4 https://doi.org/10.1016/s0960-894x(00)80263-2 Zobrazit plný text záznamu