Reaction of 5-aminopyrazole derivatives with ethoxymethylene-malononitrile and its analogues

Autor:	Atsushi Takada, Chisa Ukawa, Tamaki Hirama, Howard B. Cottam, Roland K. Robins, Katsuhiko Nagahara, Shinji Sasaoka, Hiroko Kawano
Rok vydání:	1994
Předmět:	Diethyl ethoxymethylenemalonate chemistry.chemical_compound chemistry Bicyclic molecule Pyrimidine One pot reaction Organic Chemistry Hydrazine Organic chemistry Hydrate Malononitrile
Zdroj:	Journal of Heterocyclic Chemistry. 31:239-243
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570310140
Popis:	A one-pot synthesis using 5-aminopyrazole derivatives 1 with ethoxymethylenemalononitrile (EMMN), ethyl ethoxymethylenecyanoacetate (EMCA) or diethyl ethoxymethylenemalonate (DEMM) gave pyrazolo-[1,5-a]pyrimidine compounds 2,4,8. Also, the one step reaction of EMCA with hydrazine hydrate afforded ethyl(4-ethoxycarbonyl-5-pyrazolyl)aminomethylenecyanoacetate 3c. On the other hand, the reaction of 1-substituted 5-aminopyrazole-4-carboxamide 9 with EMMN afforded pyrazolo[3,4-d]pyrimidine compounds 10.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9ae87bd3b3ac3c6a497744c8b993877a https://doi.org/10.1002/jhet.5570310140 Zobrazit plný text záznamu Plný text