Neurofilament light in plasma is a potential biomarker of central nervous system involvement in systemic lupus erythematosus
| Autor: | Guido Alves, Shunsei Hirohata, Lasse G. Gøransson, Erna Harboe, Anne Bolette Tjensvoll, Roald Omdal, Jan Terje Kvaløy, Ingeborg Kvivik, Ole Jacob Greve, Maria B. Lauvsnes, Mona K. Beyer, Kaj Blennow, Stian Maroni, Henrik Zetterberg |
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| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty Creatinine Pathology Neurology medicine.diagnostic_test business.industry Central nervous system Neurological examination Corpus callosum Pathophysiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure Cerebrospinal fluid chemistry Medicine Biomarker (medicine) Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology. 269:3064-3074 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Neuropsychiatric manifestations (NP) are common in systemic lupus erythematosus (SLE). However, the pathophysiological mechanisms are not completely understood. Neurofilament light protein (NfL) is part of the neuronal cytoskeleton. Increased NfL concentrations, reflecting neurodegeneration, is observed in cerebrospinal fluid (CSF) in several neurodegenerative and neuroinflammatory conditions. We aimed to explore if plasma NfL could serve as a biomarker for central nervous system (CNS) involvement in SLE. Sixty-seven patients with SLE underwent neurological examination; 52 underwent lumbar puncture, while 62 underwent cerebral magnetic resonance imaging (MRI). We measured selected auto-antibodies and other laboratory variables postulated to have roles in NP pathophysiology in the blood and/or CSF. We used SPM12 software for MRI voxel-based morphometry. Age-adjusted linear regression analyses revealed increased plasma NfL concentrations with increasing creatinine (β = 0.01, p |
| Databáze: | OpenAIRE |
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