Flexible synthesis of vulpinic acids from tetronic acid

Autor:	Yann Bourdreux, Ewen Bodio, Celia Billaud, Thierry Le Gall, Charles Mioskowski, Catherine Willis
Rok vydání:	2007
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Vulpinic acid Organic Chemistry Drug Discovery Iodide Pinastric acid Organic chemistry Tetronic acid Biochemistry Pulvinic acid
Zdroj:	Tetrahedron Letters. 48:6421-6424
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2007.07.094
Popis:	Several vulpinic acids were synthesized in a few steps from a single precursor, the tetronic acid. This commercial compound was converted in a few steps to an iodide. Suzuki–Miyaura cross-couplings involving this common intermediate and various arylboronates allowed to gain access to several vulpinic acids (or methyl pulvinates). Among them, two natural products, vulpinic acid and pinastric acid, were prepared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9ac721e70be204300153361d59728508 https://doi.org/10.1016/j.tetlet.2007.07.094 Zobrazit plný text záznamu Full Text from ScienceDirect