Recent Developments in the Synthesis of Pyrrolidine‐Containing Iminosugars

Autor:	Emma M. Dangerfield, Mattie S. M. Timmer, Gregory W. Haslett, Anna L. Win-Mason, Bridget L. Stocker
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Organic chemistry Lysosomal storage disorders Physical and Theoretical Chemistry Combinatorial chemistry Pyrrolidine
Zdroj:	European Journal of Organic Chemistry. 2010:1615-1637
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200901320
Popis:	As noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment of a number of diseases such as cancer, diabetes, and lysosomal storage disorders. Accordingly, much effort has been expended over the past decades in developing novel and efficient methodologies for the synthesis of iminosugars. This microreview highlights recent (post 2005) developments in the synthesis of pyrrolidine-containing iminosugars and includes discussions of methodologies such as ring-closing metathesis, aldol and pericyclic reactions, and protecting-group free strategies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9abda3f303e03c6d65fa5a3b86117525 https://doi.org/10.1002/ejoc.200901320 Zobrazit plný text záznamu Plný text