SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANALOGUES

Autor:	Mugdha R. Suryawanshi, Anshuly Tiwari, Kakasaheb R. Mahadik, Siddharth J. Modi
Rok vydání:	2019
Předmět:	Pharmacology biology Chemistry In silico Pharmaceutical Science Active site Biological activity In vitro chemistry.chemical_compound MCF-7 Biochemistry Cell culture biology.protein Epidermal growth factor receptor Triazine
Zdroj:	International Journal of Pharmacy and Pharmaceutical Sciences. :114-121
ISSN:	0975-1491 2656-0097
DOI:	10.22159/ijpps.2019v11i4.28275
Popis:	Objective: The study was aimed to investigate the cytotoxic effect of S-5H-[1,2,4]-triazino (5,6-b) indol-3-yl-3,4-phenylethane-thioate derivatives as epidermal growth factor Receptor (EGFR) inhibitors. Methods: In the present study 14 novel triazine analogues were synthesized and characterized using different spectroscopic techniques such as FT-IR, NMR and Mass Spectroscopy. The anticancer activity was performed using MCF-7 (breast cancer) and K-562 (leukaemia) cell lines. Further, molecular docking was carried out using Vlife Molecular Docking Software (MDS) on crystal structure of epidermal growth factor receptor (EGFR) to identify the binding mode of interaction with an active site. Results: Compounds MA-7, MA-8, MA-12, MA-13 and MA-14 show potent activity against cancer cell lines in the range of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9ab44433c69390fe540adacf5b095a7d https://doi.org/10.22159/ijpps.2019v11i4.28275 Zobrazit plný text záznamu