Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes

Autor: Tomas Faist, Romana Gerychová, Helena Zemlickova, Bo Jacobsson, Jan Mls, Lenka Pliskova, Petr Matlak, Radka Bolehovska, Marian Kacerovsky, Ondrej Simetka, Ivana Musilova, Petr Janku, Petr Vescicik
Rok vydání: 2019
Předmět:
Zdroj: Pediatric Research. 87:952-960
ISSN: 1530-0447
0031-3998
DOI: 10.1038/s41390-019-0692-1
Popis: To determine the association between microbial invasion of the amniotic cavity (MIAC) and the presence of Lactobacillus crispatus- or Lactobacillus iners-dominated cervical microbiota in pregnancies with preterm prelabor rupture of membrane. Next, to assess the relationship between the presence of L. crispatus- or L. iners-dominated cervical microbiota and short-term neonatal morbidity. A total of 311 women were included. Cervical samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Bacterial DNA, L. crispatus, and L. iners in the cervical samples were assessed by PCR. Cervical microbiota was assigned as L. crispatus- or L. iners-dominated when the relative abundance of L. crispatus or L. iners was ≥50% of the whole cervical microbiota, respectively. Women with MIAC showed a lower rate of L. crispatus-dominated cervical microbiota (21% vs. 39%; p = 0.003) than those without MIAC. Lactobacillus crispatus-dominated cervical microbiota was associated with a lower rate of early-onset sepsis (0% vs. 5%; p = 0.02). The presence of L. crispatus-dominated cervical microbiota in women with preterm prelabor rupture of membrane was associated with a lower risk of intra-amniotic complications and subsequent development of early-onset sepsis of newborns.
Databáze: OpenAIRE
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