Dosage of OKT3 independent of body weight: a mistake?

Autor:	Gallati H, H. A. Bock, Gilbert Thiel, Bachofen M, Pracht I, J. Landmann
Rok vydání:	1992
Předmět:	Globulin biology business.industry Clinical effectiveness medicine.medical_treatment Physiology chemical and pharmacologic phenomena Immunosuppression Mistake High effectiveness Plasma levels Body weight biology.protein Medicine business Prospective cohort study
Zdroj:	Transplant International Official Journal of the European Society for Organ Transplantation ISBN: 9783540553427
DOI:	10.1007/978-3-642-77423-2_138
Popis:	Comparing OKT3 and antithymocyte globulin (ATG) in a prospective study, the dosage difference in regard to body weight (ATG: dependent on body weight/OKT3: independent) does not introduce any obvious source of mistake concerning clinical effectiveness or side effects. One explanation for the lack of influence of body weight may be the high effectiveness of 5 mg of OKT3, reaching a maximal effect even with lower plasma levels in heavier patients. We wonder, therefore, whether the OKT3 dosage could be lowered.
Databáze:	OpenAIRE
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