Sertraline in paired blood plasma and breast-milk samples from nursing mothers

Autor:	Andrew Stocky, Graham D. Burrows, Anne Buist, Kay P. Maguire, Seetal Dodd, Trevor R. Norman
Rok vydání:	2000
Předmět:	Sertraline business.industry Desmethylsertraline Infant exposure Breast milk Excretion Psychiatry and Mental health Neurology Nursing Blood plasma Medicine Pharmacology (medical) Neurology (clinical) Hplc method business Breast feeding medicine.drug
Zdroj:	Human Psychopharmacology: Clinical and Experimental. 15:161-264
ISSN:	1099-1077 0885-6222
DOI:	10.1002/1099-1077(200006)15:4<161::aid-hup167>3.0.co;2-2
Popis:	Paired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50-150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1.76+/-1.72 was recorded. The average dose to the infants ranged from 1.1 to 31.1 mg/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright 2000 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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