High Incidence of Hepatic Encephalopathy After Viatorr Controlled Expansion Transjugular Intrahepatic Portosystemic Shunt Creation
| Autor: | Charles E. Ray, James T. Bui, Ron C. Gaba, Matthew M. Niemeyer, Albert Ren, Andrew J. Lipnik, Murad M. Alqadi, Marie-Louise Kloster, Ketan Y. Shah |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry medicine.medical_treatment Gastroenterology Mean age Hepatology medicine.disease Hospitalization rate Surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Ascites medicine Portal hypertension 030211 gastroenterology & hepatology High incidence medicine.symptom business Transjugular intrahepatic portosystemic shunt Hepatic encephalopathy |
| Zdroj: | Digestive Diseases and Sciences. 66:4058-4062 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | The Viatorr Controlled Expansion (VCX) stent-graft was designed to mitigate hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) creation. To determine the incidence and degree of HE after VCX TIPS. Thirty-three patients (M:F 17:16, mean age 58 years, mean MELD score 12) who underwent VCX TIPS between 2018 and 2019 were retrospectively studied. 11/33 (33%) patients had medically controlled pre-TIPS HE. TIPS indications included variceal hemorrhage (n = 12, 30%) and ascites (n = 21, 70%). Measured outcomes were post-TIPS HE (overall, recurrent, de novo) graded using the West Haven system, time-to-HE occurrence, HE-related hospitalization rate, and TIPS reduction rate. VCX TIPS were 8 mm in 28/33 (85%) and 10 mm in 5/33 (15%). Mean final portosystemic pressure gradient was 6 mmHg. Cumulative HE incidence post-TIPS was 61% (20/33). 1-, 3-, 6-, and 12-month HE rates were 24%, 30%, 53%, and 61% over 247-day median follow-up. Median time-to-HE was 180 days. HE grades spanned grade 1 (n = 6), grade 2 (n = 8), and grade 3 (n = 6); 9 and 11 cases were recurrent and de novo HE, respectively. Medication non-compliance/infection was implicated in HE in 9/20 (45%) cases. Medical therapy addressed HE in 18/20 (90%) cases; however, HE still resulted in 39 hospitalizations among 13 patients, and median time to first hospitalization was 75 days. Shunt reduction was necessary in 2 (10%) cases of medically refractory HE. The incidence of HE after VCX TIPS is high. Though HE symptoms may be medically controlled, hospitalization rates are high, and shunt reduction may be necessary. |
| Databáze: | OpenAIRE |
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